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Background: Differentiated thyroid carcinoma (DTC) survivors have an increased risk of cardiovascular mortality but, the pathophysiological mechanism remains largely unknown. Early treatment for high-risk DTC entails thyroid surgery, radioiodine therapy with thyroid hormone (TH)-withdrawal, and thyroxine suppression therapy (THST). During treatment, patients cycle from severe hypothyroidism to exogenous subclinical hyperthyroidism. TH changes in early DTC treatment might affec...

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ea0084op-12-62 | Oral Session 12: Nodules and Diagnostic | ETA2022

Progressive diastolic dysfunction in survivors of pediatric differentiated thyroid carcinoma

Reichert Antoinette , Nies Marloes , tissing wim , Muller Kobold Anneke , Klein Hesselink Marielle , Brouwers A.H. , Havekes Bastiaan , van den heuvel-eibrink marry , van der pal helena , plukker john , Van Santen Hanneke , corssmit eleonora , Teodora Netea-Maier Romana , Peeters Robin , van Dam Eveline , burgerhof johannes , van der Meer Peter , bocca gianni , Links Thera

Background: Pediatric differentiated thyroid cancer (DTC) has an excellent prognosis, but has unknown late effects of treatment. Initial cardiac evaluation showed subclinical diastolic dysfunction in 20% of adult survivors. In this follow-up study, we determined the clinical course of this finding.Methods: This multicenter study, conducted between 2018 and 2020, re-evaluated survivors 5 years after the first evaluation. The primary endpoint was echocardi...

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Endocrine Abstracts

Cardiac function during early treatment for differentiated thyroid carcinoma

Progressive diastolic dysfunction in survivors of pediatric differentiated thyroid carcinoma

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